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Localise, partner, adapt: A playbook for entering Indonesia

Indonesia is one of the world’s fastest-growing digital economies: young, mobile-first, and home to more than 270 million people. It is also one of the region’s most dynamic and layered markets, full of opportunity for companies that take the time to understand how it really works.

That opportunity was the backdrop for Scale Up to Global 2026: Gateway to ASEAN, a closed-door session hosted by e27 in partnership with Thailand’s National Innovation Agency (NIA) at the Mandarin Oriental Jakarta on 23 July. The premise was straightforward: as Southeast Asia’s largest economy, Indonesia is a natural gateway for regional expansion, and the event was designed to help a group of Thai scale-ups explore that market by meeting the local partners, enterprises and investors who could help them land.

Rather than a run of stage pitches, the afternoon was built around conversation, bringing together Indonesian enterprise leaders, founders, investors and government representatives for a panel discussion, followed by roundtables with each visiting company and open networking. The emphasis throughout was practical: partnerships, pilots and distribution.

The five Thai scale-ups

The showcase featured five Thai companies, each already deployment-ready at home and each addressing a sector that matters to Indonesia:

  • MUI-Robotics, an NIA-backed deeptech company whose AI-Nose platform digitises smell and taste for quality control, safety and environmental monitoring in industries such as food and beverage, cosmetics and chemicals.
  • ViaBus, a transit-technology company that digitises public transport end to end, from real-time passenger information to driver tools and fleet-management systems, already operating across Malaysia, Thailand, Laos and the Philippines.
  • Precision Dietz (Dietz.asia), a telemedicine platform for chronic-disease and non-communicable-disease care that connects hospitals, clinics and home-based monitoring into a more continuous model.
  • ALIVELOOP, a circular-materials platform that turns hard-to-recycle packaging waste, such as multi-layer foil, into industrial-grade material, with the goal of building circular supply chains across the region.
  • PraIn FinTech (ChillPay), a Bank of Thailand-regulated payment-gateway provider expanding from domestic payments into cross-border commerce, connecting Thai merchants with customers across the region.

Their sectors map neatly onto Indonesia’s own priorities: AI-driven quality control, digital health, sustainable packaging and cross-border payments.

Inside the panel discussion

The panel, moderated by e27 Co-Founder and CEO Mohan Belani, paired an incoming operator with three players who know the local market well. On the incoming side was Intouch Marsvongpragorn, Co-Founder and CEO of ViaBus. Representing the local view were Abhishek Pansari, COO of distribution company Baskit; Agustine Gunawan, SVP of partnerships at digital-health platform Alodokter; and Bayu Seto, a partner at Living Lab Ventures, the corporate venture arm of Sinarmas Land. Over an hour, the conversation moved from the big-picture opportunity to the practical steps that make a cross-border expansion work.

Also Read: Southeast Asia’s AI future is being written in Vietnamese, Thai, Indonesian

One country, many markets

A recurring theme was that Indonesia is best understood not as one market, but as many. ViaBus, which operates across Malaysia, Thailand, Laos and the Philippines, drew a contrast with its home market: Thailand is highly centralised, with most activity in Bangkok, while Indonesia is an archipelago of islands, each with distinct cultures, regulators and local players.

The company’s most useful takeaway was counter-intuitive: you may not need to start in Jakarta at all. Pansari agreed from the distribution side. Indonesia’s 270 million people are far from homogeneous; tastes, spending power and online behaviour vary widely, and trends move fast, so a single go-to-market model rarely travels well.

Regulation comes first

For companies in regulated sectors, compliance is the first thing to plan for, and it usually takes longer than newcomers expect. Gunawan spent close to a year securing a place in the Ministry of Health’s regulatory sandbox, an investment that now sets Alodokter apart.

Pansari pointed the same way from consumer goods: Halal and BPOM certification can take five to seven months, with more steps than in some neighbouring markets. The lesson for founders is to build regulatory timelines in from the start, because treating certification as an afterthought is one of the most common reasons a launch slows down.

The value of a local partner

If there was one point of consensus, it was the value of a strong local partner, for reasons beyond market knowledge. Pansari described Southeast Asia as a relationship-driven, trust-based environment: even the best product benefits from someone who can open the right doors, both to the market and to the right conversations.

Some consumer brands, he noted, came to Baskit only after trying to go it alone. Marsvongpragorn agreed while staying flexible on structure: a joint venture, vendor relationship or channel partnership can all work, but a local partner, sometimes more than one, is what activates each region.

Localisation as strategy

Gunawan offered one of the sharpest framings: in Indonesia, localisation is not cosmetic adaptation but core business strategy, and pricing is decisive. He pointed to a premium US hospital-information system that, within a month of launching, was matched by cheaper local alternatives that slotted into existing systems.

Indonesian teams are quick and resourceful, so a product priced above what the market will bear can be undercut fast, and because higher costs are passed on to the customer, pricing strongly shapes adoption. Pansari’s beauty-sector example echoed it: a brand that had thrived in China, Taiwan and Thailand found Indonesia far more price-sensitive, a market where a fresh product line may be needed every three to six months to stay ahead.

Also Read: Why agritech is key to securing long-term food resilience in Indonesia

A city as a sandbox

Seto used his time to introduce a different route into the market. Living Lab Ventures is wholly owned by Sinarmas Land and has grown from managing its parent’s balance sheet into a cross-border fund manager with external investors, backing Asia-Pacific companies that are ready to expand into Southeast Asia.

Its distinctive asset is Sinarmas Land’s BSD City: a fully private, self-operated city of around 6,000 hectares (larger than Pattaya, and roughly a tenth the size of Singapore), home to some 500,000 residents and, by Seto’s account, the second-highest GDP per capita in the country after Jakarta.

Because the group manages the city’s roads, transport, water, fibre and hundreds of CCTV cameras feeding a single command centre, BSD can serve as a live sandbox where startups run controlled pilots, backed by investment and a go-to-market programme, before committing to a national roll-out. AI runs through much of it, from traffic management upward, though Seto was candid that not every experiment works: an autonomous-bus pilot paused when regulation was not yet ready.

That kind of controlled test, he suggested, is a signal in itself, showing whether Indonesia is ready for a product, or the product ready for Indonesia. Living Lab, he added, is now actively looking for AI investments. His advice: validate the model in a captive, high-spending-power environment first, then scale with confidence.

Playbooks that have worked

Seto grounded the pitch in examples. In 2023, Living Lab invested in a Melbourne-based loyalty app for its Southeast Asian expansion and connected it into the Sinarmas ecosystem, with venues such as Plaza Indonesia and Aeon adopting it.

In 2025, it partnered with a century-old Japanese technology company to bring around 20 intellectual-property assets, spanning semiconductors, logistics and healthcare, into Indonesia through an accelerator that matched them with local startups; the cohort produced four joint ventures.

The logic is a repeatable, win-win trade: the foreign partner gains market access, while the local startup gains new innovation and handles the localisation. A product does not have to be the best in the world, Seto said. It has to be adapted into the right business model for Indonesia.

How foreign companies can stand out

Companies have been coming to Indonesia to expand and partner for years, Belani noted, prompting the panel to consider where the biggest opportunities now lie. The answers pointed less to the product than to the approach: co-development, genuine IP collaboration, and true partnership rather than going it alone.

Marsvongpragorn closed with a fitting metaphor: in a fragmented market, where Bangkok alone has around 200 bus operators, the goal is not to fight for slices of a small cake, but to work with others to bake a bigger one. For founders weighing a move into Indonesia, the message was encouraging and clear: come with an open mind, the right local partner, realistic timelines, and a willingness to adapt. For those who do, the opportunity is substantial.

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Diversify or die: The importance of multi-channel marketing in Asia

Startup ventures in Asia have been growing over the past few years; however, many young companies think marketing is optional. However, marketing is not a choice, but a must, according to analysis, and without a proper strategy and budget, no amount of effort will make the campaign successful.

As an entrepreneur says, “it takes years to make an impression,” while a partial campaign “simply does not work.” Surveys prove the point: companies that spend less than five per cent of their budget on marketing only grow in half of the cases, while 80 per cent of those that invest 5-10 per cent of their budget grow considerably.

Localise your strategy for diverse markets

There is great diversity among Asian markets, and blanket marketing techniques rarely work. Simply mimicking Silicon Valley approaches is not always helpful; for instance, the approach that works in Singapore will not necessarily work well in rural Southeast Asia. In successful Asian startups, unique playbooks are crafted because the company takes time to learn local culture and behaviours rather than mimicking global trends. Grab and Gojek gained traction by taking advantage of local trends such as cash payments and motorbike taxis as opposed to Uber.

The other key thing is trust, since most consumers in many Asian markets are skeptical and need to be won over before they fully embrace the product or service. In addition to creating demand through the use of attractive content, startups must be able to earn customers’ trust. The use of content such as guides and customer success stories helps to build credibility. PropertyGuru became a trusted name in property listing by offering simple guides in local languages.

Build credibility with content and PR

Mistake: Assuming all marketing is paid advertising. In Asia, earned media and content authority are huge assets. Neglecting public relations and expert commentary is a missed opportunity. Detutu Media notes that founders who shift from shouting into the void to borrowing existing audience through expert quotes and media coverage can land their first press mentions in 60–90 days. In other words, rather than creating content for no followers, startups should contribute expert insights to established publications. Those quick media wins instantly transfer the outlet’s credibility to the startup.

Also Read: The future of marketing isn’t about AI, it’s about judgment

Diversify channels and content

Overreliance on one platform is another mistake entrepreneurs make. 72 per cent of Asian companies say social media is their most used digital channel. Startups spend money on Facebook, TikTok, and Instagram ads. It’s a big mistake because the entrepreneur relies solely on paid advertisements while ignoring other platforms.

Overlooking content marketing and SEO may become even costlier. One marketing company suggests that “over-reliance on paid ads without content authority” is not an efficient strategy. The meaning behind that statement is clear: you spend money on ads but haven’t created any blog posts, videos, or emails for SEO and organic marketing.

It’s a huge mistake to skip influencer and community marketing, too. Consumers in Asia are loyal to the recommendations of influencers. According to Nielsen, approximately 80 per cent of Asian social users are more willing to purchase products recommended by influencers.

However, startups do not make use of that opportunity since fewer than half of the companies in Asia consider influencer marketing crucial. Entrepreneurs should use local influencers who will engage their audience and connect better with them. The same is true about email marketing. In conclusion, diversify your marketing efforts. Use paid ads, owned content, and earned marketing on social platforms.

Measure everything and stay agile

Firstly, do not fly blind. Analytics should not be skipped or neglected. Research proves that in a certain number of Asian companies (for instance, six per cent in Singapore), there is no monitoring of any kind of marketing metrics whatsoever. This is a path to failure. A startup has to measure performance and act according to its results. As a famous marketer says, acting on instincts rather than numbers is often seen but not advisable. 

Also, be prepared to pivot. If something does not work in Asia, change it. According to one marketing manual, a company should stay “agile” while working on its strategy. For example, if a copy of a landing page is confusing to the audience (ShopBack found out that it was true about the word “cashback” in SEA), then change the copy and make it beneficial to users.

Also Read: Driving the future: How AI is rewriting the global marketing roadmap for the Land Rover Defender

Invest wisely (but invest enough)

Finally, don’t starve marketing of resources. Underfunding and expecting magic are traps. As one founder remarks, too many startups launch once and “disappear” because they lack a follow-through plan. A sustained budget and timeline are essential. Hiring an all-star in-house marketing team may be out of reach, but shortcuts like always choosing the cheapest agency or tool often fail. A Singapore marketing guide cautions against “choosing agencies based only on price”. Instead, pick partners for fit and expertise.

Beware shiny-object syndrome (e.g., unvetted AI content) as well. Using generic AI text without human review can hurt authenticity. Always ensure creative quality and local relevance, even on a budget. Finally, embrace the mobile reality: Asia is largely mobile-first.

Currently in APAC, there are over 1.4 billion people (~51 per cent penetration) who use mobile internet. If your website is not optimised for mobile or neglects applications and messaging services that are popular among your local audience, then you’re missing out on customers. The digital presence of a startup needs to be fast-loading and native to how Asians consume media.

Marketing in Asia is much more complicated than in Western countries. Avoiding all these mistakes due to poor localisation, brand-building, and/or data, the underinvested startups can actually transform their marketing into a competitive advantage. Marketing done correctly can be the difference between earning your startup’s first paycheck and celebrating its tenth anniversary.

Conclusion

Learning from failures is crucial. The best thing for any startup from Asia would be planning, adapting to cultural contexts, using paid as well as earned media platforms, and constantly measuring the results. In an area where everything depends on context and trust, the most intelligent startups steer clear of making mistakes and use data-driven advertising campaigns.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. You can also share your perspective by submitting an article, video, podcast, or infographic.

The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of e27.

Join us on WhatsAppInstagramFacebookX, and LinkedIn to stay connected.

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The most sophisticated AI strategy is a puzzle hunt in Toa Payoh

In the tech ecosystem, we often talk about the next big thing in terms of code and cloud scalability. But as we move further into 2026, I’ve realised that the most complex system I am currently architecting isn’t a SaaS platform. It is a physical puzzle hunt in the heartlands of Singapore.

I call it The Kampung Files.

If you search for it, you won’t find a landing page or a venture capital pitch deck. That’s because it is currently a live pilot (running June–August 2026), designed as a navigational and cognitive challenge for adults aged 55 to 65. It is my contrarian answer to a fundamental question: How do we apply high-level systems thinking to the real world?

High-tech logic for high-touch reality

While the industry is obsessed with the Metaverse, we are ignoring a massive, systemic friction point: the ageing human mind in an increasingly complex urban environment.

The Kampung Files applies the human rapid loop to social infrastructure. We aren’t just entertaining seniors; we are pressure-testing their cognitive readiness and navigational sovereignty. We use AI to architect the logic of the puzzles, but the vibe is 100 per cent human, rooted in the history of Toa Payoh’s hawker centres and town plazas. It’s a response to the Global Loneliness Epidemic, treating social isolation not as a feeling, but as a failure of neighbourhood architecture.

Solving non-profit fatigue with systems thinking

The social sector is often plagued by symptom management. If seniors are lonely, we give them a tea session; if they are inactive, we give them a gym. But as Stanford Social Innovation Review argues, real change requires moving from fixes that fail to Root-Cause Architecture.

Also Read: Tokenised assets have moved on-chain. The liquidity has not followed

This is the same logic driving my upcoming masterclass at The Foundry Singapore, where we will be applying Radical Essentialism to social impact. We aren’t teaching theory; we are performing a Systemic Audit of how organisations operate. By turning a neighbourhood into a game board, or a social hub into a high-agency ecosystem, we reveal the leverage points where human connection actually happens.

The build engine for the streets

Designing a community puzzle hunt requires a level of originality and intent that no AI can simulate. It requires an understanding of a specific neighbourhood’s pulse. However, the execution, the logistical maps, the logic gates of the puzzles, and the pilot timelines are accelerated by an Agentic Workflow.

By separating the architecture of intent from the mechanics of execution, we allow the human-in-the-loop to focus on what matters: the cultural nuance and the user experience. This allows us to move from an idea to a street-ready pilot in weeks, not years.

The conclusion: Architect for the soul

The ultimate hack for 2026 is realising that innovation that doesn’t reach the street level is just noise. Whether it is redesigning the leadership intelligence of a company through systems like the Octiverse or helping a 60-year-old navigate Toa Payoh with more confidence, the goal is identical: to use technology to lower the friction of being human.

Stop building for the machine. Start architecting for the Kampung.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. You can also share your perspective by submitting an article, video, podcast, or infographic.

The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of e27.

Join us on WhatsAppInstagramFacebookX, and LinkedIn to stay connected.

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How AI is dismantling the risk pool in insurance

Three weeks ago, I had coffee with the chief risk officer of an Indonesian insurer who has spent the last eighteen months building an AI-driven pricing model for one of their health products. He told me the model now produces better predictions than any of their senior actuaries can defend. He also told me he was not entirely sure what to do about that.

That conversation — repeated across enough insurance C-suites — is the part of the industry’s AI story the actuarial profession is still processing in private.

I spent three years as a financial risk country manager at one of Indonesia’s largest life insurers, and have sat through enough pricing committees and product launch reviews to recognise what is happening. The discipline that holds insurance together — actuarial science — is older, more rigorous, and more sober than the rest of finance gives it credit for. It is also, more than any other part of financial services, built on a single foundational assumption: that risks can be pooled across populations and priced once.

AI is breaking the pool.

What insurance was built on

For three centuries, insurance has operated on a deceptively simple model. Gather a large population of similar risks. Estimate the expected loss across that pool. Charge each participant a premium covering their share of the expected loss plus an insurer margin. The healthier subsidise the sicker. The lower-risk subsidise the higher-risk. The pool, at scale, is more stable than any individual within it.

This is not just a pricing technique. It is the social contract of insurance. Risk pooling is what makes insurance economically valuable for the individuals who buy it.

How AI breaks the pool

Three mechanisms are reshaping the foundation at the same time.

  • Granularity. AI models can now distinguish risk at the individual level with precision that classical actuarial models cannot match. Driving telematics, wearable data, health records, and social media activity — all feed into models that price each policyholder as a pool of one. The risk pool, conceptually, dissolves.
  • Continuity. The premium that used to be set once a year, based on an underwriting moment, can now be repriced continuously against real-time data. The “policy period” becomes an accounting convenience rather than a risk reality. Adverse changes in behaviour are caught — and priced — within days.
  • Selection. With granularity and continuity comes the most consequential change. The healthiest, lowest-risk segments of the market discover they are overpaying inside the traditional pool and migrate to insurers that price them individually. The pool that remains is, by definition, riskier than the original. Premiums rise. The cycle repeats. Adverse selection — which insurance regulation has spent decades preventing — becomes structural.

Also Read: Investors bet on algorithms and insurance to tame Asia’s climate-health crisis

Why ASEAN is more exposed than the markets writing about this

Most of the public conversation about AI and insurance is happening in the United States and Europe, where regulatory frameworks for AI pricing have begun to take shape. ASEAN is running behind those discussions, not for lack of capability but because the region is running behind in everything to do with AI risk.

The exposure here is sharper for three reasons.

The data is more available. Indonesia, the Philippines, Vietnam, and Thailand have generated enormous volumes of digital behavioural data through super-apps, mobile banking, ride-hailing, and digital health. That data is less regulated and more granular than what insurers in mature markets can legally use. The capability to price individually is further ahead than the regulatory ceiling that constrains it.

The actuarial profession is thinner. The major actuarial associations in Indonesia, Malaysia, and the Philippines have credentialled practitioners in the low thousands per market, not the tens of thousands. A shock to the profession from AI displacement lands harder when the bench is smaller.

The supervisor’s capacity is uneven. Insurance regulators have been building AI competence steadily, but the depth of model risk expertise inside ASEAN supervisors is still less than what assessing AI-driven pricing genuinely requires.

What is at stake

The pool, once broken, is difficult to reassemble. The traditional life and health products that have served Indonesian households for forty years rely on cross-subsidy across populations. If the lowest-risk customers leave for individually priced products, the pool that remains is more expensive to insure — and the premium increases force the next layer out, until the product becomes unaffordable for the population it was designed to serve.

This is not theoretical. The same dynamic is already visible in segments of the US auto insurance market, where telematics-based pricing has fragmented what used to be a pooled product. It will appear in ASEAN health and life insurance next.

What regulators should be doing

Three policy responses would meaningfully shape how this lands.

Define the floor. Regulators should specify a minimum level of pooling — categories of customers that must be priced together regardless of what AI models could distinguish. Certain health conditions, genetic information, age beyond a band — these can be enforced as non-disaggregable by rule.

Require disclosure on continuous pricing. Customers whose premiums are being recalculated based on ongoing data should be told how, at what frequency, and against what data. The opacity of continuous pricing is the most consequential consumer protection question of the decade.

Also Read: The AI stack trap: Why more AI tools aren’t translating into more growth

Build supervisor capacity now. AI insurance pricing will be deployed faster than supervisors can train to assess it. The window to bring model risk expertise into OJK, MAS, BNM and their equivalents is short.

The macro stakes

Insurance was built on the assumption that risks could be pooled. AI is making it possible to price individually at scale. The institutions that succeed in the next decade will be the ones that figure out how to use the new capability without dismantling the social contract the old model rested on. The regulators that succeed will be the ones who defined what counts as pooling before the market decided for them.

The actuarial profession will adapt. It always has. What will not adapt easily is the public’s trust in insurance as a mechanism that distributes risk fairly. That trust is harder to rebuild than the pricing model is to replace.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. You can also share your perspective by submitting an article, video, podcast, or infographic.

The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of e27.

Join us on WhatsAppInstagramFacebookX, and LinkedIn to stay connected.

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Will Bitcoin hold its US$64,500 line in the sand, or are we heading straight for a test of the US$63,170 support level?

Bitcoin slipped 1.28 per cent to US$65,127.33 over the past 24 hours, tracking a 1.38 per cent decline in total crypto market capitalisation, and the story behind that move tells us far more about positioning fragility than about any fundamental shift in conviction. Two macro forces converged to trigger the selloff.

Stalled Senate negotiations on the CLARITY Act crushed near-term hopes for regulatory clarity, while Brent crude oil surged past US$101 per barrel amid Middle East tensions, reigniting inflation fears that ripple directly into risk-asset pricing. When legislators cannot agree on a framework and energy costs climb at the same time, traders pull back from anything that smells like speculation. Bitcoin, as the most liquid proxy for crypto risk, absorbed the initial hit and dragged the rest of the market along.

But the macro trigger only lit the fuse. The real damage came from the derivatives complex. Bitcoin liquidations jumped 74.57 per cent to US$49.41 million in a single day, with long liquidations accounting for US$41.89 million of that total. That is not a gentle unwind. That is a cascade of overextended bulls getting margin-called into a thin order book, each forced sale pushing price lower and triggering the next liquidation in a vicious feedback loop.

The broader market saw over US$182 million in total liquidations, and the CoinGlass data I reviewed paints a picture of a market clearing excess leverage on both sides rather than reacting to one clean directional catalyst. Aggregated figures showed roughly US$79.58 million in leveraged positions wiped out, with short liquidations near US$39.58 million and long liquidations around US$4.0 million in one reporting window, though cross-exchange inconsistencies mean the true total likely runs higher. The discrepancy itself tells you something important about how fragmented and opaque this market remains.

Also Read: Bitcoin volume drops 6.14%, and everyone calls a bottom, I disagree

Ethereum bore the heaviest individual burden, leading all assets with US$41.15 million in 24-hour liquidations and dropping 2.51 per cent to US$1,881.63. The 24-hour heatmap showed Ethereum at US$38.10 million and Bitcoin at US$23.74 million in total liquidation volume, dwarfing every other token by a wide margin.

Here is what strikes me as most telling. Bitcoin logged roughly US$1.20 million in liquidations, split between US$638,500 in longs and US$563,700 in shorts, while Ethereum saw US$1.73 million in liquidations, split between US$873,400 in longs and US$854,200 in shorts.

That near-balance in the two largest assets signals a broad deleveraging phase, not a one-way squeeze. The market is shaking out crowded bets in every direction, which typically accompanies mean-reverting, choppy conditions rather than the start of a sustained trend in either direction.

The exchange-level data reinforces this reading. In the most recent four-hour window, US$9.61 million in liquidations hit the tape. Binance led with US$5.30 million, representing 55.19 per cent of the total, and long liquidations accounted for 63.79 per cent of that total. OKX followed with US$1.23 million and a similar long-heavy split at 63.2 per cent.

Bybit recorded US$1.02 million with an unusually high 84.42 per cent long share, while Aster posted US$539,120 with longs representing 91.78 per cent. Gate also reported a high long share at 85.34 per cent. Hyperliquid stood apart with a nearly even split of 52.99 per cent longs and 47.01 per cent shorts across US$474,640 in liquidations, hinting at genuine two-sided turbulence.

When I see venues like Bybit and Aster showing such extreme long concentration, I read that as crowded directional bets getting punished by intraday whipsaws, not by a structural breakdown in demand.

Also Read: Bitcoin just broke US$66,000: Is this the start of the next bull run or a trap for late investors?

For Ethereum specifically, the technical picture demands close attention. The 78.6 per cent Fibonacci retracement level at US$1,860 and an ascending trendline from the June low form a critical support confluence. Resistance sits near US$1,955, and short liquidation concentrations cluster around US$1,958 to US$1,965, which could fuel a squeeze if price approaches that zone.

The RSI hovering near 36 suggests oversold conditions that historically precede consolidation or a bounce. Spot ETF inflows of US$72.64 million on July 22 provide an underlying institutional bid, though repeated ecosystem exploits, including a US$7.5 million Verus bridge attack within a broader US$35 million attack wave, dent confidence and keep sentiment cautious among retail participants.

Bitcoin faces its own technical crossroads. Price trades below the 200-day moving average at US$72,687 but above the 50-day at US$62,786. The US$64,500 level represents immediate support, and a break below it risks testing US$63,170 near the 50-day line. A daily close above US$66,800 resistance would signal genuine buyer conviction returning to the table. With a 79 per cent probability of a September Fed rate hike and WTI crude above US$90, the macro backdrop offers little comfort for aggressive risk-taking in the near term.

My read on this market is straightforward. We are watching a leverage-driven shakeout play out within a range-bound regime, not the beginning of a structural bear market. The balanced long and short liquidations in major assets, the rotation into smaller tokens, and the minimal spot movement relative to derivatives carnage all point to position crowding as the culprit. Traders who reduce leverage, widen their liquidation buffers, and avoid tight stops near obvious levels in thin-liquidity altcoins will navigate this stretch far better than those chasing direction on every candle.

The next meaningful signal will come from open interest trends, funding rate normalisation, and whether Senate lawmakers break the CLARITY Act deadlock. Until then, expect choppiness, respect the liquidation heatmap, and treat every sharp move as a positioning event rather than a verdict on the future of crypto.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. You can also share your perspective by submitting an article, video, podcast, or infographic.

The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of e27.

Join us on WhatsAppInstagramFacebookX, and LinkedIn to stay connected.

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Hong Kong’s pitch to SEA: “We want to be your super partner”

Sophia Chong, Executive Director at HKTDC

At Siam Paragon’s Speaker Lounge in Bangkok, against the backdrop of SITE 2026, Sophia Chong, Executive Director at the Hong Kong Trade Development Council (HKTDC), sat down to explain why Thailand, and Southeast Asia more broadly, has become central to Hong Kong’s global strategy.

The occasion was a fitting one: HKTDC had just received the Global Partnership Award from Thailand’s National Innovation Agency (NIA), marking eight years of collaboration since the two organisations signed their first memorandum of understanding in 2018.

Also Read: How Thailand’s NIA is driving global collaboration for Thai innovation

“We are very honoured and privileged, because the prime objective of visiting SITE is to receive this award, which exemplifies the longstanding partnership between NIA and HKTDC,” Chong said. “We started our MOU as early as 2018, and since then we have been organising mutual missions — Hong Kong startups to SITE and other Thai events, and NIA also bringing Thai startups to Hong Kong, to events such as InnoEX, as well as Food Expo, because Thailand is also very advanced in food tech.”

Bangkok’s growing role in a 51-office network

Thailand’s importance to HKTDC isn’t incidental; it’s structural. The council operates 51 offices worldwide, seven of them across ASEAN, with Bangkok serving as the regional hub overseeing Southeast Asia and South Asia, including India. That positioning reflects a broader shift in Hong Kong’s trade patterns since the pandemic.

“We observed a shift in the demographics as well as in the global trade scenario,” Chong explained. “ASEAN has become the second-largest export market for Hong Kong. From 2019 to 2025, we’ve witnessed our exports grow by more than 60 per cent, which is a very huge number.”

This growth has been reinforced by Hong Kong government policy. Under the GoGlobal Task Force — led by the Secretary for Commerce and Economic Development and delivered jointly by HKTDC, InvestHK and a number of professional bodies and service providers — eligible mainland Chinese companies are being actively guided into Southeast Asian markets, including Thailand, via Hong Kong. “So that’s why RCEP is becoming increasingly important,” Chong noted, referencing the Regional Comprehensive Economic Partnership. “For many companies, ASEAN has strategic proximity, and Hong Kong is a growing market with a growing role.”

Hong Kong’s case as a global springboard

Asked how Hong Kong differentiates itself from Singapore, the other major hub Southeast Asian founders often weigh, Chong pointed to the city’s “One Country, Two Systems” framework as its defining advantage. “Hong Kong has a unique advantage under one country, two systems, under the Chinese Mainland,” she said. “Because of our common law system, our free flow of capital, free flow of people and information, and our own currency — all of this, together with a strong intellectual property protection scheme, forms the foundation for doing business with the international community.”

That foundation, she added, works both ways: mainland Chinese companies use Hong Kong as a springboard to the world, while international firms use it to enter the Chinese Mainland with reduced risk. “Hong Kong service providers understand the culture, understand the system, understand how it works, so we provide a very good partnership before going into the market.”

Chong outlined three “drive engines” underpinning Hong Kong’s value proposition, echoed recently by the city’s Financial Secretary: its role as an international financial centre, its evolution as a sophisticated trade hub moving up the value chain into advanced manufacturing and branding, and its emerging status as an innovation and technology hub that commercialises research for global markets.

Also Read: Why the tech world is heading to Hong Kong in April 2026

The figures back up the financial claim. Hong Kong became the world’s top IPO fundraising centre last year, raising the equivalent of roughly US$37 billion across 119 new listings, with subsequent capital raises adding a further US$66 billion, pushing total capital raised past US$100 billion in a single year. “This really is a record,” Chong said.

Biotech, green finance and the Greater Bay Area advantage

For biotech and healthcare startups specifically, Hong Kong has introduced listing rules, Chapters 18A and 18C, allowing pre-revenue, pre-profit companies to raise capital provided they meet the criteria set by the Securities and Futures Commission and the Hong Kong Stock Exchange. “This has already facilitated hundreds of companies being listed and raising capital in Hong Kong in the healthcare and biotech space,” Chong noted.

Layered on top is access to the Guangdong-Hong Kong-Macao Greater Bay Area, home to some 87 million people across nine mainland cities plus Hong Kong and Macau. Through the Hong Kong and Macao Medicine and Equipment Connect introduced in 2021, drugs and medical devices approved in Hong Kong can be fast-tracked into 71 designated medical institutions across the Bay Area. “As of 30 April this year, we already have 71 drugs and 91 medical devices going into practice in the Greater Bay Area,” Chong said.

“Some of those drugs from the US, have since been approved by the National Medical Products Administration in Beijing to apply nationwide, so you can see, step by step, how Hong Kong leads into the Greater Bay Area and then into the mainland market of 1.4 billion people.”

Green finance is another pillar Chong highlighted as an underappreciated growth area. Hong Kong has arranged green and sustainable bonds for eight consecutive years, a first in Asia, with the government issuing roughly US$32 billion in green bonds since 2018 across more than 110 projects covering green buildings, waste management and resource recovery. Green startups in the city have grown 150 per cent over five years, now numbering around 265.

“We think that green startups and green compliance are the current high-growth area in the world,” she said.

From trade facilitator to startup accelerator

Beyond capital markets, Chong emphasised HKTDC’s evolving role as an ecosystem builder. Startups landing in Hong Kong become eligible for government funding schemes such as the Innovation and Technology Fund, administered by the Innovation and Technology Commission, and gain access to incubators including Hong Kong Science Park and Cyberport. InvestHK, meanwhile, handles the practical side of relocation, from company setup to finding schools for founders’ children.

“HKTDC will provide marketing and business-matching opportunities through our sectoral focus exhibitions,” Chong said, pointing to more than 40 world-class events spanning healthcare, logistics, electronics and lifestyle sectors, alongside international missions to CES in Las Vegas and Viva Technology in Paris.

Much of this activity is now anchored around Hong Kong’s Northern Metropolis, a new innovation corridor bordering Shenzhen. The Hong Kong Innovation and Technology Park has received a fresh government injection of roughly US$1.3 billion this year, on top of about US$2.2 billion previously committed, with two further parks — San Tin Technopole and Hung Shui Kiu — each drawing a similar US$1.3 billion investment to attract R&D, advanced manufacturing and production-focused technology firms.

Also Read: Why Hong Kong’s metro just became every marketer’s dream

“So HKTDC’s role is not just event organising, but rather business matching and deal-making,” Chong said. “We are moving up the value chain, apart from being the superconnector, we want to give value add, and ultimately be a super partner, so that startups can enter the market with reduced obstacles.”

Looking ahead

With Hong Kong’s trade with ASEAN growing nearly 64 per cent between 2019 and 2025, Chong sees the relationship deepening further over the next two years, particularly in biomedicine, green technology, robotics and the low-altitude economy. For Southeast Asian founders weighing where to scale next, her message was clear: Hong Kong isn’t just a financial centre, but a proven pathway into one of the world’s largest and fastest-growing markets.

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Ropedia raises US$22M to build the data layer for robots that understand the real world

Robots are getting better at seeing, speaking, and planning. What they still struggle with is the messy business of doing.

For a machine to reliably pack a box, wipe a table, load a warehouse shelf or assist someone at home, it needs more than internet text and video clips. It needs to understand grip, weight, timing, movement, and context — the kind of physical judgement humans build through repeated experience. Singapore-based Ropedia is betting that this missing layer will become one of the most important infrastructure markets in artificial intelligence (AI).

Also Read: “Data, not hardware, is the real bottleneck in humanoids”: Matrix Robotics CEO Allen Zhang

The startup has raised US$22 million in pre-Series A funding, taking its total funding to US$30 million. The round was backed by venture investors focused on AI, deeptech and infrastructure in Southeast Asia, though the company did not disclose specific investor names.

A previous round included investors and super angels connected to Google, Andreessen Horowitz, NVIDIA, and Amazon.

Ropedia will use the capital to expand its real-world data collection operations into Southeast Asia and North America, grow its Singapore and US teams, and increase manufacturing of its wearable capture hardware. It also plans to strengthen its data platform with annotation tools, quality analytics, and compliance systems, while expanding research into data foundation models and world models, AI systems designed to build an internal understanding of how the physical world behaves.

Why physical AI needs different data

The surge of interest in “physical AI” follows the rapid advances made by large language models. The basic idea is to bring AI out of screens and into machines that can operate in the real world, from industrial robots and autonomous vehicles to humanoids and home assistants.

But robots face a harder data problem than chatbots. Text-based AI systems were trained on enormous volumes of written material already available online. Robotics data is scarcer, more expensive to collect, and far more dependent on context. A video of a person lifting an object may show the action, but not always the force used, the hand motion, the depth of the scene or the subtle adjustments made along the way.

That is where Ropedia is positioning itself. Its platform captures what the company calls multimodal human experience data: egocentric video, depth, motion, and audio collected through proprietary wearable hardware. The data is then synchronised, processed and converted into datasets that robotics and embodied AI developers can use to train their models.

Also Read: Rise of the machines: 20 robotics startups shaping Southeast Asia’s future

“A robot can’t play baseball by watching a video any more than you could learn to ride a bike by reading about it,” said Zhaoxi Chen, CEO and co-Founder of Ropedia. “The robot must understand what it’s like to grip a bat and know the timing it takes to hit a ball.”

That explanation gets to the heart of the challenge. The next stage of robotics is not just about recognition; it is about interaction. Machines need training data that records how humans move through kitchens, workshops, factories, offices and streets, and how those movements change across cultures, layouts and environments.

A Singapore base for a global robotics data play

Founded in the second half of 2025, Ropedia is headquartered in Singapore and also has an office in Mountain View, California. Its founding team combines academic research and industry experience in computer vision and embodied AI.

Chen’s work spans 3D computer vision, generative foundation models and multimodal content generation. CTO Fangzhou Hong previously worked on Meta’s egocentric multimodal intelligence research, while Chief Scientist Ziwei Liu is an Associate Professor at Nanyang Technological University in Singapore.

That Singapore connection matters. Southeast Asia is becoming a useful testbed for physical AI because of its mix of advanced manufacturing, logistics hubs, dense urban environments and service-heavy economies. Singapore, in particular, has pushed robotics in sectors such as healthcare, cleaning, logistics and food services, partly because of labour constraints and its high-cost operating environment.

The region also offers environmental diversity that robotics companies cannot easily replicate in a lab — humid warehouses, crowded retail spaces, mixed transport systems and varied household settings.

Also Read: dConstruct lands US$125M Series A to scale robotics for GPS-denied environments

For Ropedia, expanding data collection in Southeast Asia could help its customers train models that are less brittle when deployed outside controlled environments. A robot trained only on neatly staged factory or home data from one geography may fail when faced with different lighting, room layouts, tools, packaging, languages or user behaviour.

The company claims its approach can reduce data-collection costs by up to 50x compared with traditional methods. Its wearable device, called HOMIE, has entered mass production to support larger deployments. Ropedia says it already serves more than 20 robotics and foundation model companies across North America, China and Singapore, in areas including embodied AI and spatial intelligence.

Its flagship dataset, Xperience-10M, is described by the company as one of the world’s largest human experience datasets. Ropedia also offers custom Data-as-a-Service products for robotics and embodied AI developers that need task-specific or geography-specific data.

The competitive field

Ropedia is entering a market that is still forming, but not empty. Its competitors are likely to come from several directions. Data-labelling and AI infrastructure companies such as Scale AI, Appen, and TELUS International AI have long served machine learning teams, though much of their work has focused on labelling rather than capturing physical interaction data at source.

Synthetic data companies such as Datagen have targeted computer vision and simulation use cases, offering another way to train models when real-world data is scarce. Meanwhile, robotics and embodied AI startups such as Physical Intelligence, Skild AI, and Figure AI are building their own model and data pipelines, which could reduce their reliance on outside providers.

Ropedia’s bet is that independent, large-scale, real-world human experience data will become a shared infrastructure layer, much like cloud infrastructure did for software startups.

The question is whether robotics companies will buy that layer externally or continue building it in-house. In AI, the answer has often been mixed: companies outsource some infrastructure when it saves time, but keep strategically sensitive data close. Ropedia will have to prove not only that its datasets are cheaper and broader, but that they are reliable, compliant and meaningfully improve model performance.

That compliance layer may become more important as physical AI leaves research labs. Data captured in homes, factories, and public spaces can raise privacy and consent issues, especially when audio, video, and movement data are involved. Southeast Asia’s regulatory environment is fragmented, with different data protection rules across markets, so any company building regional data infrastructure will need careful governance from the start.

Also Read: Beyond productivity: How AI can make work more human

Still, the timing is favourable. Investors are hunting for the next infrastructure layer after the boom in large language models, while robotics companies are under pressure to show that their systems can move beyond demos. If Ropedia can turn human physical experience into structured, reusable training data, it could sit close to the picks-and-shovels layer of the robotics economy.

Chen frames the opportunity in infrastructure terms: cloud computing needed data centres, language AI needed internet text, and physical intelligence will need real-world interaction data. The claim is ambitious, but the direction of travel is clear. If AI is to move from answering questions to handling objects, opening doors and working beside people, it will need to learn from the physical world, not just look at it.

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“The AI did it” is not a defence; it is a confession

If the reported OpenAI-Hugging Face cyber incident stands up under scrutiny, the most alarming part is not that an AI system found a way to cheat a test. It is that one of the world’s most powerful AI companies appears to have built the conditions for that failure, then rushed to describe the result as something close to autonomous misbehaviour.

That framing matters. A great deal.

According to the account so far, OpenAI’s models, operating with loosened safeguards inside a sandbox, allegedly escaped the testing environment, used stolen credentials, discovered a vulnerability, accessed Hugging Face’s systems and pulled secret information to game an evaluation. This is being described as unprecedented. Fair enough. But “unprecedented” should not become a euphemism for “nobody is accountable”.

Also Read: The future isn’t people or machine — It’s people with machine

The more useful way to read this episode is brutally simple: humans set the goal, humans relaxed the constraints, humans connected the system to a world full of targets, and humans are now tempted to speak as if the machine developed intentions of its own. That is not a technical nuance. It is the entire story.

Stop anthropomorphising the machine

Every time the industry says an AI system “went rogue”, it quietly shifts blame away from the people and organisations that designed, deployed and incentivised it.

Machines do not wake up with malice. They optimise against the environment and permissions given to them. If an AI model was told to pursue “complex attack paths”, then found a way to break out of a loosely controlled sandbox and target a third party, that is not evidence of machine agency in the moral sense. It is evidence of a badly bounded experiment.

This is where the AI industry remains maddeningly slippery. The same companies that insist their systems are not conscious are suddenly happy to imply a kind of machine cunning when something goes spectacularly wrong. It is a convenient trick: anthropomorphise the product, depersonalise responsibility.

For startup founders and builders across Southeast Asia, that should set off sirens. The region has spent the past decade learning, often the hard way, that “move fast and break things” is just Silicon Valley’s more stylish phrase for pushing risk downstream. If a frontier AI lab can normalise the idea that a breakout attack is an unfortunate by-product of innovation, smaller companies will absorb the lesson that messy collateral damage is acceptable so long as it happens in the name of capability.

It is not acceptable.

The sandbox excuse is not a defence

The industry also leans too heavily on the word “sandbox”, as if it were a magic ward against consequences.

A sandbox is only as secure as its boundaries, access controls and failure assumptions. In cybersecurity, there is no medal for saying the intrusion was meant to happen in a controlled environment when the obvious problem is that it did not stay there. That is like assuring the public a chemical spill happened in a lab, while the toxic sludge is already in the river.

And let us not pretend this is just a niche technical mishap inside a single company’s testing stack. AI labs are now building systems designed to write code, probe systems, automate workflows, search across tools and make multi-step decisions with minimal human oversight. In plain English: they are creating machines that can chain actions together in ways that look increasingly like operational autonomy, whether or not the machine “understands” what it is doing.

Also Read: AI human hybrid support: Why customers still prefer real conversations

That is exactly why governance cannot be bolted on after the demo.

We have seen this pattern before

The OpenAI episode would be disturbing enough as a standalone story. It is more troubling because it fits a broader pattern: powerful institutions deploying AI into sensitive domains first, then acting surprised when the harms are real, scalable and difficult to reverse.

The Middle East offers the starkest example. AI is not some hypothetical future risk in warfare; it is already entangled in present conflict. Project Nimbus, the US$1.2 billion cloud computing contract involving Google, Amazon, and the Israeli government, became a global flashpoint precisely because cloud and AI infrastructure do not exist in a moral vacuum.

Reporting has also drawn attention to AI-assisted targeting systems, such as Lavender and Gospel in Israel’s war in Gaza. Whatever one’s politics, the core point is unavoidable: AI systems are already being embedded in kill chains, surveillance architectures and state power.

Governments elsewhere have misused algorithmic systems in less visibly violent but still deeply damaging ways. In the Netherlands, automated risk tools played a notorious role in the childcare benefits scandal, where thousands of families were wrongly accused of fraud.

In the UK, the Home Office’s visa streaming algorithm was scrapped after criticism that it baked nationality-based discrimination into immigration decisions. These were not science-fiction breakdowns. They were policy failures dressed in the language of efficiency.

Private sector misuse has been no better. Amazon famously abandoned an internal AI recruiting tool after it showed bias against women. In the US health insurance sector, companies have faced lawsuits over algorithmic systems allegedly used to deny or limit care decisions at scale. Clearview AI built a business by scraping billions of facial images without consent, turning human faces into a searchable database before society had any meaningful chance to debate the ethics.

The common thread is not that AI became evil. It is that institutions used it in ways that amplified their existing power, opacity and appetite for expedience.

Southeast Asia should pay very close attention

Why should a Singapore-based startup publication care about a frontier AI lab in San Francisco allegedly hacking an AI company in New York? Because Southeast Asia is precisely the kind of region where the consequences of weak AI governance will be imported long before effective protections are built locally.

Many startups here will not train frontier models. They will build on top of them. They will integrate agentic tools into customer service, finance, logistics, healthcare, education, and government services. They will inherit both the capabilities and the failure modes of systems designed elsewhere, often under commercial pressure to ship quickly and ask questions later.

That makes accountability standards non-negotiable. If a model can access the internet, use credentials, discover vulnerabilities and target third-party systems, then every company deploying AI agents needs to treat them less like chatbots and more like junior operators with the potential to create legal, financial and reputational damage at machine speed.

And no, “the model did it” cannot become a valid excuse in boardrooms, procurement meetings or regulatory hearings.

The real divide is not open versus closed

This incident will also inflame the stale open-source versus closed-model argument. But the sharper lesson is not that open models are safer or closed models are safer. It is that concentrated power plus low transparency is a dangerous mix.

When only a handful of companies can inspect the most capable systems, set the test conditions, define the guardrails and narrate the failures, the public is asked to trust institutions that have every incentive to manage perception. That is not a safety regime. That is a branding strategy.

Also Read: Most AI projects don’t fail on technology, they fail on the workflow nobody fixed first

Startups, regulators and enterprise buyers in Southeast Asia should insist on something more boring and far more useful: auditability, liability, independent red-teaming, incident disclosure rules and procurement standards that do not treat frontier model providers as priesthoods.

The OpenAI-Hugging Face incident, if borne out, is not a warning that AI has become too human. It is a warning that the people building it are still too comfortable externalising the risk. That is the scandal. And the longer the industry hides behind the mythology of rogue machines, the more damage it will do before anyone forces it to grow up.

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Singapore’s Tikva targets solid cancer barrier with US$8M Series A

For years, cell therapy has carried one of oncology’s most striking contradictions. It has changed the outlook for some blood cancer patients, yet has struggled to make the same impact in solid tumours, which account for the vast majority of cancer cases worldwide.

Singapore-based Tikva Allocell is trying to push through that wall with a different kind of off-the-shelf cell therapy. The biotechnology company has raised US$8 million in Series A financing led by Kantharos Capital, with the proceeds earmarked for studies needed before human testing and a planned Investigational New Drug, or IND, submission by the end of 2026.

Also Read: Singapore’s Biobot Surgical raises US$15.6M to take prostate-care robot global

If regulators clear the application, Tikva plans to begin a Phase 1 clinical trial of its lead candidate, TAVST01, in patients with advanced B7-H3-positive cancers at sites in Singapore and the US.

That dual geography matters. For Singapore, which has spent years building its biomedical research base, the trial would place a homegrown cell therapy company on a path that connects local clinical infrastructure with the world’s largest biotech market. For patients, the more important question is whether Tikva’s approach can solve a problem that has repeatedly defeated the field: how to make donor-derived immune cells survive long enough inside a patient to attack solid tumours.

A different starting point for cell therapy

TAVST01 targets B7-H3, a protein found across several difficult-to-treat solid tumours, including lung, breast, prostate, pancreatic and paediatric cancers. B7-H3 has attracted interest because it is often highly expressed on cancer cells and in the tumour microenvironment, while its presence in normal tissues appears more limited, making it a potential target for cancer therapies.

The company’s approach begins not with a generic donor T cell, but with Epstein-Barr virus-specific T cells. Epstein-Barr virus, or EBV, is extremely common; most adults carry it from a past infection, and the immune system typically keeps a long-lived population of EBV-fighting T cells on patrol. Tikva’s bet is that these cells may offer the durability that conventional donor-derived cell therapies have lacked.

“Cell therapy has transformed the treatment of blood cancers but has repeatedly stalled at the solid-tumour door; the donor cells either fail to persist or are eliminated by the patient’s immune system before they can act,” said Ivan Horak, founder and CEO of Tikva Allocell.

“We started from a different place: a virus-fighting T cell the body naturally sustains, armed to seek out B7-H3 and engineered to withstand the rejection that defeats most donor-derived approaches, with minimal gene editing,” he added.

Also Read: AI is detecting cancer earlier in Southeast Asia but our policies and capital have not caught up

Tikva’s platform, called ALLO SerpinB9 EBVST, is licensed exclusively from Baylor College of Medicine and further enhanced through the company’s own protein-engineering work. The cells are fitted with a B7-H3-targeting receptor and an optimised version of SerpinB9, a naturally occurring inhibitor of granzyme B. Granzyme B is one of the enzymes immune cells use to kill their targets.

In simple terms, a patient’s immune system would normally recognise donor cells as foreign and attack them. Tikva’s SerpinB9 “armour” is designed to help the therapy resist that attack, remain active for longer, and reduce one of the central weaknesses of allogeneic, or donor-derived, cell therapy. The company also says the approach is designed to minimise graft-versus-host disease, a serious complication in which donor immune cells attack the patient’s healthy tissues, while requiring only limited gene editing.

Why solid tumours remain hard

The promise of cell therapy is best known through CAR-T treatments, where a patient’s immune cells are engineered to recognise cancer and then infused back into the body. These therapies have delivered strong results in some blood cancers, but solid tumours are a different battlefield.

Tumour masses are physically harder for immune cells to penetrate. They often create an immunosuppressive microenvironment, a local shield that weakens immune attacks. Antigens, the markers therapies use to identify cancer cells, can vary across tumour cells, allowing some cancer cells to escape. And when cells come from a donor rather than the patient, the recipient’s immune system may quickly eliminate them.

Allogeneic therapies are attractive because they can be manufactured in advance, stored, and potentially given to many patients without waiting weeks for a bespoke treatment. That could make them cheaper, faster and more scalable than patient-specific therapies. But the trade-off has been persistence: if the donor cells disappear too quickly, they may not have time to do meaningful work.

Tikva’s answer is to use a type of immune cell the body is already used to maintaining, then engineer it to both recognise B7-H3 and resist immune rejection. In preclinical work, the company says TAVST01 has shown potential to kill tumour cells directly and to remodel the tumour microenvironment that has held back other solid-tumour cell therapy attempts.

The next step is more demanding. IND-enabling studies will test whether the therapy is safe enough, consistent enough and well-characterised enough for regulators to allow human trials. For a young biotech, this stage is capital-intensive and unforgiving, which makes the Series A round central to Tikva’s timetable.

A Singapore biotech with global ambitions

Tikva’s financing also reflects a broader shift in Southeast Asia’s life sciences ecosystem. The region is better known in tech circles for fintech, e-commerce and logistics startups, but Singapore has long treated biomedical science as a strategic sector, supported by research institutes, hospital networks, manufacturing capacity and regulatory infrastructure.

Still, building a biotech company in Southeast Asia is very different from building a software startup. Timelines are longer, capital requirements are heavier, and the path to revenue usually runs through clinical data, regulatory approval and partnerships with larger pharmaceutical companies. For Singapore-based biotechs, the challenge is not only to do credible science, but to connect early research with global clinical and commercial pathways.

Tikva appears to be structuring itself with that in mind. By planning clinical sites in both Singapore and the US, it can anchor development in its home market while engaging the regulatory and clinical ecosystem that often determines whether biotech assets attract global investors, partners or acquirers.

“Our investment reflects strong conviction in both Tikva’s science and its leadership team,” said Terence Tan, Managing Partner at Kantharos Capital. “Tikva is addressing fundamental challenges that have constrained allogeneic cell therapies, and we believe its ALLO SerpinB9 EBVST platform can extend the reach of cell therapy to solid-tumour patients who today have limited options.”

The competitive field

Tikva is entering a crowded and technically difficult race. Globally, companies such as Fate Therapeutics, Allogene Therapeutics, Caribou Biosciences, and Atara Biotherapeutics have explored allogeneic cell therapies, while larger pharmaceutical and biotech players continue to invest in CAR-T, T-cell receptor therapies and natural killer cell platforms. In solid tumours, B7-H3 is also being pursued through different modalities, including antibody-drug conjugates, bispecific antibodies and cell therapies. That means Tikva will not be judged on novelty alone. It will need to show that its EBV-specific, SerpinB9-armoured cells can persist, avoid serious safety issues, and generate signals of tumour activity in patients who have few remaining options.

Also Read: Danish startup Alcolase is betting its future on Asia’s drinking culture

For now, the company’s story remains preclinical. The US$8 million round does not prove that TAVST01 will work in humans, nor does it remove the biological risks that have humbled many solid-tumour programmes before it. But it does give Tikva enough runway to test a clear hypothesis: that a naturally persistent virus-specific T cell, properly engineered, can become a practical off-the-shelf weapon against solid cancers.

If that hypothesis survives clinical testing, the implications would reach well beyond one Singapore startup. It would strengthen Southeast Asia’s claim to a place in high-end therapeutic innovation, not merely as a trial site or manufacturing base, but as a source of globally relevant biotech platforms.

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Ecosystem Roundup: When AI acts, humans are still responsible

When OpenAI recently disclosed that Hugging Face had been breached through access to its pre-release models, the instinctive question was technical: how did the system fail? But the more important question was human: who decided to grant that access, under what safeguards, and who owns the consequences?

That question sits at the heart of one of the most corrosive ideas spreading through boardrooms across Asia, that when an AI system causes harm, the humans behind it bear diminished responsibility. They do not.

Every AI deployment is a chain of human decisions: what data to use, what outcomes to optimise for, what risks to accept, and what oversight to build in. When that chain produces harm, it does not matter that a model made the final call. The people who designed, deployed, and profited from that system made it possible.

In Southeast Asia, where AI is being embedded into lending, hiring, healthcare, and content moderation at speed, this accountability gap is not theoretical. It is a liability hiding in plain sight.

Blaming the AI is not a defence. It is a confession.

REGIONAL

Grab backs Vietnam EV charging startup EBOOST: The ride-hailing giant’s strategic investment in EBOOST signals its intent to anchor EV infrastructure in Vietnam as competition among charging networks intensifies across the country.

MAS pushes digital assets beyond speculation as Coinbase expands: Singapore’s MAS is broadening its digital assets framework beyond crypto trading, aligning with Coinbase’s Singapore expansion to position the city-state as a serious institutional digital-asset hub.

Maribank receives approval to launch in the Philippines: Sea Limited’s digital bank Maribank is set to become the Philippines’s seventh digital bank, deepening Sea’s financial services footprint across Southeast Asia beyond its Singapore base.

Omio raises US$10M to expand into Japan and SEA: The European multimodal travel booking platform secured fresh funding to enter Japan and Southeast Asia, targeting fragmented regional rail and ferry markets underserved by existing OTAs.

Vietnam proposes banning under-16s from posting on social media: A draft law targeting minors’ social media activity would prohibit those under 16 from publishing content, adding Vietnam to a growing list of governments tightening youth online protections.

Monks Hill Ventures shuts Indonesia office: The Singapore-based VC’s closure of its Jakarta office reflects a broader pullback in SEA venture activity, raising questions about long-term institutional commitment to Indonesia’s startup market.

Lazada founder raises capital for new AI-first wealth startup: Pierre Poignant, co-founder of Lazada, is building an AI-driven wealth management platform, betting that Southeast Asia’s growing affluent class remains underserved by traditional private banking.

GoRocky acquires Kindred to expand Philippine telehealth: Philippine telehealth startup GoRocky’s acquisition of Kindred consolidates the country’s digital health market as demand for remote medical services continues to outpace supply of licensed practitioners.

Singapore refill startup Ecoworks secures Lam Soon investment: Ecoworks, which makes concentrated refill cleaning products, has drawn strategic backing from FMCG group Lam Soon, signalling growing corporate appetite for sustainable consumer goods in Singapore.

Hong Kong pitches SEA founders on ‘super partner’ positioning: Hong Kong’s bid to reframe itself as a strategic gateway rather than a rival to Singapore reflects intensifying competition for regional startup and capital flows.

Singapore’s startup rise sharpens focus on corporate venturing: A surge in Singapore-based startups is drawing more corporates into early-stage investing, with corporate VC arms competing more directly with traditional financial VCs for deal access.

Malaysia and Hong Kong ink capital markets collaboration deal: The two markets formalised a deal to strengthen cross-border capital market connectivity, a move that could ease dual-listing pathways and cross-border fundraising for SEA founders.

South Korea fines TikTok US$7M for ad data violations: Korea’s personal data protection regulator levied the fine over TikTok’s use of personal data for targeted advertising without adequate user consent, the latest regulatory strike against the platform in Asia.


INTERVIEWS & FEATURES

“The AI did it” is not a defence; it is a confession: As AI is embedded into consequential decisions, accountability cannot be outsourced to the model; those who deploy it own the outcomes, full stop.

Wiz AI’s Jennifer Zhang exits to build US AI startup: Zhang’s departure from the president role at Wiz AI to launch her own venture underscores the pull of the US AI market even for operators embedded in Southeast Asia’s ecosystem.

B Capital names Andrew Jackson as first Chief AI Officer: The Singapore-rooted VC’s appointment of a dedicated Chief AI Officer and General Partner signals a structural shift in how top-tier funds are integrating AI into investment operations.

Corporate VC vs financial VC: what Applied Ventures offers founders: An inside look at Intel’s venture arm makes the case that strategic value — supply chain access, co-development, and distribution — matters as much as capital for deep tech startups.

An honest look at SEA venture in 2026: A candid investor perspective on where SEA VC stands mid-year, including which sectors still attract conviction capital and where the funding drought shows no sign of easing.

Deeptech and a fracturing world: SEA needs a new playbook: As geopolitical fault lines redraw global supply chains, this feature argues SEA deep tech founders must rethink go-to-market, funding, and manufacturing strategies built for a more integrated world.

Digital nomads find SEA’s welcome mat has fine print: Visa rules, tax obligations, and bureaucratic friction are quietly eroding Southeast Asia’s appeal as a remote work destination despite governments’ public enthusiasm for attracting global talent.

A playbook for entering Indonesia: localise, partner, adapt: Practical market-entry guidance for founders targeting Indonesia stresses that cultural localisation and deep local partnerships matter far more than product quality alone.

Ropedia raises US$22M to build data layer for real-world robots: Singapore-based Ropedia secured Series A funding to develop the data infrastructure that enables robots to interpret and navigate unstructured real-world environments, a foundational bottleneck for commercial robotics.

Singapore’s data analysts trust AI to work, not to think: A survey of Singapore-based data professionals finds practitioners are comfortable delegating execution to AI tools but remain deeply reluctant to cede analytical judgement or strategic interpretation.


INTERNATIONAL

Travis Kalanick’s robotics firm raises US$1.7B led by a16z: The former Uber CEO’s new venture secured one of the year’s largest robotics rounds, with Andreessen Horowitz leading, a signal that autonomous systems are drawing serious institutional capital again.

SoftBank nears US$40B loan syndication for OpenAI: The Japanese conglomerate is close to finalising a massive credit facility to fund OpenAI’s expansion, underscoring SoftBank’s deepening financial entanglement with the world’s most prominent AI lab.

OpenAI’s AI spending reaches US$750B: OpenAI has disclosed cumulative AI infrastructure expenditure of US$750B, a figure that illustrates the extraordinary capital intensity of frontier model development and the gap widening between top-tier labs and everyone else.

ServiceNow invests US$40M in India’s BusinessNext for APAC banking: The US enterprise software firm’s strategic investment targets autonomous banking deployment across Asia Pacific, with financial institutions in SEA among the primary target markets.

Google justifies AI spending with booming cloud revenue: Alphabet’s latest earnings show Cloud revenue accelerating sharply, giving Google the financial cover to continue heavy AI infrastructure investment, with direct implications for SEA cloud pricing and enterprise adoption.

Tesla’s robotaxi programme stalls amid operational setbacks: Early operational data from Tesla’s robotaxi rollout shows the service underperforming expectations, a cautionary data point for SEA mobility startups tracking autonomous vehicle timelines.

Jack Dorsey launches Buzz to take on Slack with AI agents: Buzz integrates AI agents directly into team communication workflows, positioning it as an agentic-first alternative to Slack as enterprise AI adoption accelerates.

Meta exits major clean energy pact as gas buildout grows: Meta’s withdrawal from a prominent clean energy alliance signals a strategic pivot toward natural gas to power its AI data centres, a tension SEA governments will watch as they negotiate data centre energy commitments.


CYBERSECURITY

AI phishing is making trust APAC cybersecurity’s weakest link: Hyper-personalised AI-generated phishing attacks are exploiting the social trust norms prevalent in APAC business culture, making the region disproportionately vulnerable compared with Western markets.

AI already inside the enterprise. Has Asia’s security kept up?: An assessment of enterprise AI adoption in Asia finds security infrastructure lagging significantly behind deployment speed, with shadow AI use creating blind spots in corporate risk management.

OpenAI says Hugging Face was breached via pre-release models: OpenAI disclosed that Hugging Face systems were compromised through access to pre-release models, exposing vulnerabilities in how AI model-sharing platforms manage access controls and pre-deployment security.


SEMICONDUCTOR

AI chip startup Etched hits US$10.3B valuation: Etched, which builds chips purpose-built for transformer models, reached a US$10.3B valuation backed by prominent investors, a major vote of confidence in application-specific AI silicon over general-purpose GPU architectures.

AMD secures Anthropic investment to challenge Nvidia in AI chips: The Anthropic-AMD partnership to develop alternative AI training chips is the clearest signal yet that major AI labs are actively funding supply-chain diversification away from Nvidia dependency.

South Korea’s chipmakers eye opportunities amid US-China tensions: Korean semiconductor firms are repositioning to capture market share as US-China chip restrictions create gaps in the global supply chain, with SEA nations emerging as potential beneficiaries of supply chain rerouting.

Singapore’s Tikva Allocell raises US$8M Series A: Tikva Allocell, a Singapore-based biotech developing cell therapy manufacturing technology, secured Series A funding led by Kantharos Capital to scale its proprietary cell processing platform.


AI

Anthropic updates Claude voice mode with stronger models: Claude’s upgraded voice mode now runs on more capable underlying models, narrowing the gap with OpenAI’s Advanced Voice Mode and intensifying competition in the real-time conversational AI segment.

Most AI projects fail on workflow, not technology: Organisations rushing to deploy AI without first redesigning underlying processes are setting themselves up for failure — a pattern particularly prevalent among SEA enterprises adopting AI for the first time.

AI-powered automation reshaping SME operations in SEA: Small and medium enterprises across Southeast Asia are deploying AI to automate back-office functions, with early adopters reporting measurable gains in operational efficiency and cost reduction.

How AI is dismantling the risk pool in insurance: AI-driven hyper-personalisation of insurance pricing is eroding the actuarial foundations of traditional risk pooling, with significant implications for insurtech regulation and access to coverage across SEA.

AI empowered teams are shrinking and that’s harder than it sounds: As AI tools enable smaller teams to do more, the organisational and human costs of headcount reduction are proving far more complex than efficiency metrics suggest.

The end of headcount as a success metric: Venture-backed startups and their investors are rethinking how scale is measured as AI enables leaner teams to generate outsized output, challenging a decade of growth-stage hiring orthodoxy.

The real difference between OpenAI and Anthropic: Beyond capability benchmarks, the divergence between OpenAI and Anthropic’s strategies becomes starkest when AI becomes a commodity — one built for scale, the other for trust.

Taiwan’s stablecoin moment: NTD could outshine the dollar: A case for Taiwan dollar-backed stablecoins argues that Taiwan’s trade surplus, currency stability, and semiconductor-driven export economy make it a compelling anchor for a non-USD stablecoin, relevant as SEA explores digital currency infrastructure.


THOUGHT LEADERSHIP

SEA startups can no longer sit on the fence on tech stack: Geopolitical fragmentation is forcing SEA founders to choose sides on cloud, chip, and software infrastructure, a decision with long-term strategic consequences they can no longer defer.

Southeast Asia as a climate capital proving ground: SEA is emerging as the test bed for climate finance models that blend blended finance, carbon markets, and impact investing, a convergence that could attract a new class of global capital.

Thought leadership as a market entry tool: Founders expanding beyond their first market can use strategic content and public positioning to build trust and brand credibility in new geographies before sales teams arrive.

The most sophisticated AI strategy is a puzzle hunt in Toa Payoh: Singapore’s grassroots AI adoption story, told through a community scavenger hunt, argues that the most durable AI strategies are built bottom-up, not imposed top-down by strategy consultants.

Multi-channel marketing is survival, not strategy, in Asia: Single-channel dependency is a growth ceiling for Asian brands. This piece makes the case that diversified marketing is now a baseline operational requirement, not a competitive differentiator.

Why remote no longer means anywhere: The era of frictionless remote work is ending as employers tighten location requirements and compliance burdens grow, with real consequences for SEA’s talent mobility and hiring models.

Product management as method acting: The best PMs don’t just research users; they internalise them, adopting their mental models and constraints to build products that solve real problems rather than assumed ones.

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