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Asia’s new AI wave: Startups driving smarter healthcare, safer roads, better living

Artificial intelligence (AI) is no longer the future; it’s the present engine propelling Asian startups to tackle real-world challenges across healthcare, travel, mobility, customer experience, security, and more.

The confidence behind their progress isn’t just hype: Asia‑Pacific’s healthcare AI market alone is expected to surge from about US$860 million in 2025 to US$3.27 billion by 2031, growing at a robust 24.9 per cent CAGR.

In parallel, Singapore is leading Southeast Asia in healthcare AI investment, with its market projected to surpass US$1.5 billion by 2025, thanks in large part to initiatives like Smart Nation, AI Singapore, and Startup SG.

Enter a new generation of homegrown AI innovators. From Singapore’s ConnectingDNA (genomics-powered well-being) to Taiwan’s dentall.ai, Thailand’s Spacely AI, and Indonesia’s bubbME.AI, these startups reflect a vibrant ecosystem.

Others span from mobility safety with Vision AI in Rider Dome (Singapore) to unified enterprise AI platforms like Shieldbase. Their missions are diverse, but one thing connects them all: the drive to solve deep-rooted, everyday problems using artificial intelligence.

Below is the list of several emerging Asian startups that leverage artificial intelligence to solve specific problems in their respective markets:

ConnectingDNA

Profile Country Founding year
ConnectingDNA seeks to use human connection, data technology, holistic solutions, and knowledge of our individual genetics to help people achieve sustainable well-being and greater longevity. Singapore 2021

Leamigo

Profile Country Founding year
An B2B platform for agents to book global activities and transfers, with direct access to 20,000 suppliers. India 2017

dentall Co

Profile Country Founding year
It provides a dental cloud-based practice management system in Taiwan, called “dentallHiS”. It has developed “dentall.ai,” a software empowered by generative AI technology to elevate communication and treatment quality between dentists and patients. Taiwan 2016

Rider Dome

Profile Country Founding year
Rider Dome is a motorcycle safety solution powered by Vision AI. The system detects and alerts riders to critical road threats aimed for motorcycle OEMs and large fleets. Singaopore 2021

Spacely AI

Profile Country Founding year
Spacely aims to revolutionise how the world visualises architecture and interior design. Based in Bangkok and serving 1,500+ design firms across 50+ countries, it claims to have delivered over two million AI-generated renders. Thailand 2023

Bubbme AI

Profile Country Founding year
bubbME.AI is an integrated and gamified adolescent healthcare monitor that combats bullying and gender-based violence using AI and Big Data. Indonesia 2021

Good Bards

Profile Country Founding year
Good Bards is an agentic AI for marketing with all the integrations and resources mid-sized businesses need to inform, automate and optimise their customer engagement. Singapore 2023

Shieldbase AI

Profile Country Founding year
Shieldbase helps enterprises adopt AI in the workplace safely and effectively, with a strong emphasis on data privacy, compliance, and governance. Its AI Operating System integrates fragmented tools, workflows, and data sources into a unified, secure platform. Singapore 2024

Hello Ello

Profile Country Founding year
ELLO is an AI-powered home monitoring assistant that transforms your existing camera feed into natural, intelligent conversations. Singapore 2025

AidMi

Profile Country Founding year
AidMi is building an AI-powered clinical assistant that helps doctors deliver better care–before, during, and between visits. Singapore 2024

MUI-Robotics

Profile Country Founding year
MUI-Robotics provides Sensory AI, an AI-powered smell-sensing technology that imitates the human sense of smell. Its tech is used in quality control and environmental monitoring. Singapore 2021

Momos

Profile Country Founding year
Momos builds AI that helps multi-location brands grow by caring for every customer at every store 24/7. Its AI-native Customer Platform powers over 20,000 locations globally across QSR, F&B, retail, healthcare, and personal care. Singapore 2021

Obiguard

Profile Country Founding year
Obiguard is an AI risk management platform built to align with your business needs, protect critical assets, and ensure safe, compliant AI deployment across industries. Malaysia 2024

 

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Earth VC backs nuclear innovator Aalo Atomics to address Southeast Asia’s data centre power crunch

Singapore-focused Earth Venture Capital has invested in the US$100 million Series B funding round of US-based Aalo Atomics, a next-generation nuclear energy startup.

Valor Equity Partners is the lead investor.

The funding will be used to construct Aalo’s inaugural nuclear power plant, the Aalo-X, at the Idaho National Laboratory in the US. With criticality targeted for next summer, this project will become the first advanced nuclear facility to commence operations in the US in decades.

This deal comes a year after Earth VC’s investment in Aalo’s US$27 million investment round in 2024.

Also Read: Is Southeast Asia’s data centre boom headed for a PR crisis?

Crucially for the tech sector, this demonstration plant will be paired with an experimental data centre built directly alongside it, showcasing a novel approach to addressing AI’s insatiable energy demands.

The AI-energy nexus and Asia’s urgent need

The implications for Asia, particularly Southeast Asia, are profound. The region is grappling with an escalating energy crisis driven by rapid digital expansion.

Between 2019 and 2023, data centre capacity in Southeast Asia expanded by nearly 30 per cent, consuming an astonishing four to five times more power per square metre than traditional factories. In India, data centre capacity is projected to double by 2026, a direct reflection of surging demand from digital and AI infrastructure.

Across the broader Asia-Pacific region, inventory growth exceeding 20 per cent year-on-year paints a stark picture, with forecast electricity shortfalls of 15-25 GW by 2028. This data underscores an urgent, unmet requirement for clean, reliable baseload energy. Aalo’s modular reactor technology aims to address this pressing issue.

In contrast to conventional gigawatt-scale nuclear installations, Aalo’s reactors are engineered for factory production and rapid, fleet deployment. This design philosophy enables their swift and efficient integration to power critical infrastructure such as data centres, industrial clusters, and utility networks.

Aalo’s strategic roadmap involves scaling from its demonstration plant to deploying thousands of “Aalo Pods.” Each Pod is envisioned to comprise five Aalo-1 reactors and one turbine, designed to power data centres at an unprecedented scale.

The company’s long-term ambition is to slash electricity costs to an exceptionally competitive US$0.03 per kWh, positioning nuclear energy to rival renewables and natural gas in affordability.

Also Read: The AI-energy paradox: Will AI spark a green energy revolution or deepen the global energy crisis?

For Earth VC, Aalo’s Series B achievement resonates deeply with its core mission: to champion ambitious deep tech innovators capable of facilitating the decarbonisation of Emerging Asia and safeguarding prosperity on a habitable planet.

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“Don’t build for Demo Day”: Zhang Fan on the enduring truths of entrepreneurship in the AI era

Zhang Fan’s journey with founders–from Maxscend’s slow climb to billions in market capitalisation to mentoring AI-driven startups across Southeast Asia–highlights a simple but powerful truth: technology may start the story, but it’s people, persistence, and practical value that finish it.

As Southeast Asia cements its position as a rising innovation hub, his words resonate as both a challenge and a reminder: tomorrow’s difference makers aren’t just those who shine on stage and quietly keep going when the odds stack high.

Zhang Fan, former founding Managing Partner of Sequoia Capital China and Visionary Partner of the Lee Kuan Yew Global Business Plan Competition (LKYGBPC) by the Singapore Management University, has spent decades backing founders who redefine industries. From early bets on China’s semiconductor pioneers to mentoring student-led startups in Southeast Asia, he has consistently emphasised grit, resilience, and practical value over hype.

Also Read: 60 global startups to compete for US$2M prize at LKYGBPC grand finals

e27 spoke with him to discuss his investment philosophy, lessons from the early days of Maxscend Microelectronics, and why Southeast Asia is brimming with entrepreneurial promise.

You’ve often said you don’t evaluate startups based on hype. Where does that philosophy come from?

It comes from experience. In the early 2000s, I invested in a small startup called Maxscend Microelectronics. The company wanted to build an IC chip that would let mobile phones receive terrestrial TV signals. It felt like a bold, inevitable convergence between broadcasting and mobility at that time.

I didn’t start with spreadsheets; I started with a conversation. These engineers had just returned from Silicon Valley, and their conviction about China’s rising electronics demand was palpable. That belief compelled me to back them.

But the journey was brutal. The company’s first three products failed commercially. They were technically sound, but the market wasn’t ready. Yet what impressed me was how the team refused to give up. By 2010, the team realised the real pain point was in radio frequency (RF) front-end components for smartphones. It quietly pivoted, partnered with TSMC, and launched a low-noise amplifier that global smartphone makers embraced.

Fast-forward: By 2019, Maxscend went public in Shenzhen, and today, it is worth over RMB 41 billion (US$5.7 billion). The lesson? Technology alone doesn’t build enduring companies. It’s about teams that persist, learn, and adapt until they find the right fit.

What do you look for in founders when backing early-stage startups?

I dive into the messy parts: revenue dips, broken funnels, failed go-to-market attempts. I do this not to challenge them but to understand the gravity they’ve fought against.

Resilient founders aren’t afraid of failure; they treat it as feedback. Even now, in the age of AI, where possibilities seem limitless, my compass hasn’t changed. I ask: Does this solve a pain so essential that people will demand it ten years from now?

If the answer is no, then it’s just another flashy demo. That’s why I value practicality over presentation, what I call “practical value.”

Can you share examples of founders who embody this kind of resilience?

Absolutely. Look at Alexandr Wang, who founded Scale AI. He built it to solve a data-labelling challenge he personally encountered. That kind of firsthand problem-solving creates lasting impact.

Closer to home, Lenard Zhuang in Southeast Asia is modernising construction safety using AI-powered video analytics. It’s not glamorous, but it addresses a mission-critical need that saves lives and reduces risk in an overlooked sector.

When local understanding meets global ambition, you get resilience that’s hard to replicate.

You’ve been actively involved with Southeast Asia’s innovation ecosystem. What excites you about it?

The energy here is palpable. Beyond the sheer scale of opportunity, what excites me most are the founders, especially student founders, who are solving real problems.

Singapore Management University’s Whitepaper on Innovation and Entrepreneurship highlights how universities in this region are becoming hubs for scalable and sustainable talent. I’ve seen it firsthand while reviewing submissions for the Zhang Fan Global AI Initiative Award, part of the LKYGBPC.

These founders aren’t chasing applause. They’re building purposeful solutions, often with sharp market understanding and a clear focus. It’s deeply energising to witness.

What will you look for in the next generation of entrepreneurs when you meet them in Singapore this September?

I’ll apply the same lens I used with Maxscend two decades ago. I want to see if they have discipline, humility, and practical value. Do they listen harder after each failure? Do they adapt instead of giving up? Are they building something that will stand the test of time?

Also Read: Why startup founders should not escape failure

True success doesn’t lie in the spotlight. It’s built in those quiet, determined moments when founders keep pushing forward long after others have stopped believing.

Finally, what advice would you give to young founders just starting out?

Start close to home. The strongest ideas often come from problems you’ve personally faced. Stay resilient; failure isn’t the end, it’s the process. And always focus on value that lasts.

Don’t build for Demo Day. Build for the day when your solution becomes indispensable to your customers, even ten years from now. That’s how you create enduring companies.

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Powell’s pivot: How Jackson Hole reshaped markets and what comes next

The financial landscape presents a compelling narrative of shifting tides and strategic recalibration as we navigate the final stretch of August. Recent developments emerging from Jackson Hole have fundamentally reshaped market expectations, creating a domino effect across asset classes that demands careful dissection.

Federal Reserve Chair Jerome Powell’s carefully calibrated remarks last Friday did far more than hint at potential policy shifts; they effectively slammed the door on prolonged restrictive monetary policy while opening a wide window for immediate easing.

This pivot represents a significant departure from the Fed’s previous stance and carries profound implications for investors globally. Market participants responded with characteristic speed, pushing major US indices to fresh record highs as the S&P 500 gained 1.52 per cent and the tech-heavy Nasdaq surged 1.88 per cent.

The Dow Jones Industrial Average joined this upward trajectory, climbing 1.89 per cent to touch uncharted territory, a development underscored by the US government’s strategic investment in a major semiconductor manufacturer, which provided additional tailwinds for industrial and technology sectors.

Inflation cools, optimism rises

This renewed optimism stems directly from Powell’s acknowledgement that inflation has sufficiently cooled to warrant policy adjustment. His speech deliberately avoided the cautious hedging that characterised previous communications, instead emphasising the Fed’s readiness to act decisively should inflation continue its descent toward the two per cent target.

The immediate market reaction proved remarkably consistent across fixed income and currency markets. Treasury yields tumbled across the curve with the benchmark 10-year note falling 7.4 basis points to 4.254 per cent, while the two-year note dropped 9.5 basis points to 3.696 per cent. This yield compression reflects investor conviction that the current restrictive policy stance is temporary.

Concurrently, the US Dollar Index retreated 0.92 per cent as capital flowed toward risk assets while gold prices rebounded one per cent on the dual catalysts of dollar weakness and heightened rate cut anticipation. These movements collectively signal a powerful shift in market psychology where the so-called Fed put, the implicit promise of central bank support during market stress, has been reactivated with unusual clarity.

Also Read: Blockchain technology: Revolutionising global payment solutions and cross-border remittance

Earnings season exposes a split reality

The earnings season provides a critical counterpoint to this macro optimism, revealing a more nuanced corporate reality beneath the surface. While the much-discussed Magnificent Seven technology giants delivered robust results exceeding lowered expectations, the broader market tells a different story. Analysis of S&P 500 earnings revisions shows a troubling pattern of downward adjustments for the remaining 493 companies.

This bifurcation creates a dangerous illusion where headline index performance masks underlying weakness in the economic mainstream. Investors now turn their attention to the final wave of quarterly reports from key technology players, including Nvidia, CrowdStrike, Snowflake, and Autodesk, alongside consumer stalwarts Lululemon and Dollar General.

These results will serve as crucial stress tests for both the technology sector’s growth trajectory and consumer resilience amid persistent inflationary pressures. The market eagerly awaits these reports not merely for individual company performance but for what they reveal about broader economic health and corporate pricing power.

Asia’s liquidity pressures and regional sentiment

Asian markets present their own complex dynamics, particularly Hong Kong’s interbank rate market, which has exhibited unusual volatility. The one-month Hong Kong Interbank Offered Rate Hibor has surged dramatically from 1.0 per cent on August 11 to 2.77 per cent as of August 22.

This sharp increase reflects significant tightening in short-term liquidity conditions, likely driven by seasonal funding demands and potential regulatory adjustments. Such movements warrant close monitoring as they can transmit stress through global financial channels.

Also Read: Jackson Hole looms: Can Powell save markets from a global risk meltdown?

Despite these regional headwinds, Asian equity markets opened higher during early trading sessions today, suggesting regional investors remain influenced by the broader risk-on sentiment emanating from Powell’s comments. Yet US equity index futures currently indicate a potential pullback at today’s open, introducing an element of caution that underscores the market’s fragile equilibrium.

Crypto’s reaction: from Bitcoin to Ethereum

The cryptocurrency sector experienced particularly dramatic fluctuations following Powell’s speech, creating a fascinating case study in market psychology and whale behaviour. Bitcoin initially surged above US$67 000 following the dovish Fed commentary as traders anticipated lower interest rates would boost risk asset valuations.

However, this rally proved short-lived with the digital asset subsequently declining approximately two per cent. Blockchain analytics firms identified significant movement by large holders shifting substantial Bitcoin positions into Ethereum, a trend that accelerated over the weekend.

Lookonchain data revealed one prominent wallet recently converted part of its 100,784 Bitcoin holdings to acquire 62,914 Ethereum tokens while simultaneously establishing a large derivatives position. This strategic rotation by major players suggests a fundamental reassessment of digital asset allocation priorities, where Ethereum increasingly appears as the preferred vehicle for institutional exposure to the crypto ecosystem.

Ethereum’s technical indicators present both opportunity and warning signs that demand careful interpretation. The cryptocurrency’s 30 day Market Value to Realised Value MVRV ratio has reached 15 per cent a threshold historically associated with profit taking and potential corrections.

Analytics firm Santiment explicitly warns that this constitutes a danger zone that could trigger selling pressure if Ethereum fails to break US$5,000 in the near term. Yet this short-term caution contrasts with the more favourable long-term MVRV ratio of 58.5 per cent, indicating substantial unrealised gains for patient holders.

Additional bullish signals include the declining supply of Ethereum held on exchanges, which suggests growing investor confidence and reduced immediate selling pressure. Combined with rising staking participation and expanding decentralised finance DeFi activity, these fundamentals position Ethereum as the structural cornerstone of the crypto economy rather than merely a speculative alternative.

Strategic imperatives for investors

For investors navigating this complex environment, several strategic imperatives emerge clearly.

Also Read: The intersection of tech and climate change: 5 key forces that will redefine the global market

First, the renewed viability of the Fed puts creates a tactical opportunity to accumulate quality assets during periods of volatility. Well-capitalised investors should view market pullbacks as entry points for fundamentally strong companies, particularly those demonstrating pricing power and resilient cash flows.

Second, the rotation from Bitcoin to Ethereum observed among major holders warrants serious consideration as it reflects a maturation of institutional crypto strategies. Dollar cost averaging into Ethereum provides a prudent approach to managing volatility while maintaining exposure to the asset’s long-term potential.

Third, investors should actively hedge existing cryptocurrency positions using options or futures contracts to protect against potential corrections, especially given the current MVRV warning signals.

Fourth, attention must remain fixed on Ethereum’s technological roadmap, where continued protocol upgrades like further implementation of EIP 4844 will drive sustainable value creation beyond mere speculation.

The road ahead: Volatility and value

The coming weeks will test the durability of this optimistic market posture as investors confront key data points, including the August CPI inflation report, consumer sentiment figures, and potential developments on trade policy. Historical precedent suggests September often brings increased market volatility; the current environment differs significantly from past cycles due to the Fed’s explicit commitment to policy normalisation.

While technical indicators show investor positioning has become somewhat extended, introducing near-term correction risks, the fundamental backdrop of potential rate cuts, combined with resilient corporate earnings, supports continued market advancement. The critical distinction this time involves the quality of the underlying assets driving the market.

Unlike previous cycles, where broad-based speculation fuelled gains, the current environment rewards careful stock selection focused on companies with demonstrable earnings power and sustainable competitive advantages.

This nuanced market landscape demands intellectual rigour and disciplined analysis from investors. The days of indiscriminate buying are over, replaced by an era requiring a granular understanding of both macroeconomic currents and individual company fundamentals.

Powell’s Jackson Hole speech has reset market expectations in profound ways, creating both opportunity and risk that will define investment outcomes for the remainder of 2024. Investors who combine patience with strategic precision while avoiding emotional reactions to short-term volatility will best position themselves to navigate the complex months ahead.

The market’s message is unambiguous: lower rates are coming, but their arrival does not guarantee universal gains. Success will belong to those who recognise that the Fed’s policy shift merely creates favourable conditions; the real work of identifying enduring value remains squarely the investor’s responsibility.

As we move toward September’s pivotal Federal Reserve meeting, the financial world watches with bated breath, knowing that the decisions made in the coming weeks will reverberate through markets for years to come.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. Share your opinion by submitting an article, video, podcast, or infographic.

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From Bangkok to billions: Inside OpenAI’s startup growth playbook

Marc Manara

What does it take for a 10-person team to generate US$200M in annual recurring revenue? Or for a startup to reach US$250M ARR in under two years, without a massive fundraising round?

For Marc Manara, head of startups at OpenAI, the answer lies in a disciplined blend of speed, focus, and the intelligent use of AI infrastructure. Speaking at OpenAI x SCB 10X in Bangkok, Manara pulled back the curtain on how the company works with founders worldwide, and why its platform is becoming a launchpad for the next generation of market leaders.

From workflows to full-stack agents

Manara’s definition of an AI “agent” was intentionally functional: a workflow to guide behaviour, tools to expand capability, and guardrails to ensure appropriate, ethical outcomes. In his telling, agents are not novelties; they are the new operational backbone.

The real shift, he argued, will be from isolated AI functions to full-stack solutions capable of handling multi-step processes, integrating into existing workflows, and adapting across industries.

The 2025 investment lens

OpenAI’s priorities for the year ahead underscore this trajectory:

  • Models and customisation
  • An agents platform
  • Multimodality

Multimodality, where text, audio, and images flow seamlessly through one system, is already reshaping product design. Manara framed it as a “first-class capability,” not an experimental feature.

Lean teams, outsized returns

Two examples dominated the discussion:

  • Cursor: 20 employees, US$250M ARR in just 21 months
  • Midjourney: 10 employees, US$200M ARR in two years

Both exemplify what Manara calls seedstrapping: building significant traction and revenue before pursuing large-scale funding. The model favours rapid iteration, tight feedback loops, and a relentless focus on product-market fit.

Also Read: AI gold rush: How OpenAI’s Singapore expansion could reshape the startup ecosystem

Beyond the API

OpenAI’s engagement with startups goes far beyond providing API access. Programmes include:

  • Enhanced concierge support: solution architects, account escalation, and dedicated office hours
  • Exclusive resources: API credits, invite-only technical sessions, and “build hours” with OpenAI experts
  • Direct influence: alpha and beta access to shape the product roadmap

This is underpinned by OpenAI’s internal loop: Research → Apply → Deploy → Repeat, which Manara urged founders to replicate.

For those paying close attention

Not everything shared in Bangkok was on the slides. Manara pointed to two resources that, while technically public, are rarely promoted and often overlooked: one on the emerging frontier of text-to-speech, and another on a discreet pathway to privileged access within OpenAI’s startup ecosystem.

I will share both with readers who follow me here on e27. Think of it as a private briefing for those who are actively paying attention.

A global play, from Bangkok

The keynote underscored a bigger truth: global-scale AI infrastructure is no longer a Silicon Valley monopoly. As OpenAI expands its reach into Southeast Asia, the advantage will go to founders who can not only access these capabilities but operationalise them faster than their peers.

Want the two “golden nuggets” I mentioned? Follow me here on e27 and I’ll send them to you directly. Sometimes, knowing where to look is the real advantage.

Editor’s note: e27 aims to foster thought leadership by publishing views from the community. Share your opinion by submitting an article, video, podcast, or infographic.

Enjoyed this read? Don’t miss out on the next insight. Join our WhatsApp channel for real-time drops.

Image courtesy of the author.

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